The KINERET logo and generic name (anakinra)

KINERET Support Program

How should I inject KINERET?

Learn from your healthcare team and develop a routine.

When your child starts KINERET treatment, you will receive injection training from the professionals at your hospital or doctor's office. Then the time will come for you to continue with daily KINERET injections at home.

Whether you are a parent injecting your child or a patient learning to self-inject, it is important to learn the correct way to safely handle syringes and to give injections so you can gain the confidence you need.

Watch the KINERET injection video

What happens if my child has an injection site reaction?

Most injection site reactions are temporary, and there are tips to help address them.

  • Skin reactions are the most common side effect with KINERET and may appear as redness, swelling, bruising, itching, or stinging of the skin at the injection site
  • Injection site skin reactions are most common during the first month of treatment and usually last about 14 to 28 days

To help address injection site reactions:

  • Cool the site with a cold compress or ice pack for a few minutes, both before and after the injection
  • Don't skip the warm-up step of bringing KINERET to room temperature
  • Apply hydrocortisone or an antihistamine cream to your injection site
  • Rotate sites to avoid soreness. A diary or the KINERET Injection Tracker can help keep track of sites
  • Don't inject into skin that is red, bruised, tender, or hard

How do I get KINERET?

Kineret ON TRACK® will arrange for KINERET to be shipped directly to your home.

KINERET is supplied in single-use, prefilled, graduated glass syringes containing 100 mg of KINERET solution. KINERET is dispensed in a 7-day pack and most people receive their KINERET in a shipment of 4 packs (containing a total of 28 injections), but this may vary depending on your prescription.

KINERET syringe and packaging

How should I store KINERET?

KINERET should be stored in a refrigerator.

KINERET should be refrigerated at between 36°F to 46°F (2°C to 8°C).

Store KINERET in its original carton and away from light.

Discard any syringe that has been left out of the refrigerator for more than 12 hours.*

Do not freeze or shake KINERET.

*We recommend you take your KINERET syringe out of the refrigerator to allow it to warm to room temperature before injection.

What injection resources are available?

A variety of resources contain information on injecting KINERET.

As a complement to the initial injection instructions you may receive from your doctor's office, you can use these KINERET training materials to help you get started.

If you would like to request in-home injection training or get advice via telephone from a KINERET Trained Nurse, Kineret ON TRACK® may be able to help.

KINERET® (anakinra) injection tracker

A printable sheet for keeping track of your injection sites

KINERET treatment guide

A brochure with information about how KINERET works, how to store and inject KINERET, and details about the services of Kineret ON TRACK®

KINERET instructions for use

Instructions for storing and injecting KINERET
The Kineret ON TRACK® logo and generic name (anakinra)

If you would like to request injection training or get advice via telephone from a KINERET Trained Nurse, Kineret ON TRACK® may be able to help.

Learn more about the services available for eligible patients by visiting Kineret ON TRACK®

INDICATIONS

What is KINERET (anakinra)?

KINERET is a prescription medicine called an interleukin-1 receptor antagonist (IL-1Ra) used to:

  • Reduce signs and symptoms and slow the damage of moderate to severe active rheumatoid arthritis (RA) inadults when one or more other drugs for RA have not worked
  • Treat people with a form of Cryopyrin-Associated Periodic Syndromes (CAPS) called Neonatal-OnsetMultisystem Inflammatory Disease (NOMID)
  • Treat people with Deficiency of Interleukin-1 Receptor Antagonist (DIRA)

Kineret is not for children with Juvenile Rheumatoid Arthritis.

IMPORTANT SAFETY INFORMATION

Who should not receive KINERET?

You should not receive KINERET if you are allergic to proteins made from bacteria called E. coli or any of the ingredients in KINERET.

What should I tell my healthcare provider before taking KINERET?

You should tell your doctor if you:

  • Have an infection, a history of infections that keep coming back, or other problems that can increase your risk of infections.
  • Are scheduled to receive any vaccines since people using KINERET should not receive live vaccines.
  • Have kidney problems.
  • Are pregnant, planning to become pregnant, or breastfeeding. It is not known if KINERET will harm your unborn baby or passes into your breastmilk. You and your healthcare provider should decide if you will use KINERET or breastfeed.

What are the serious side effects of KINERET?

KINERET can lead to serious infections, including tuberculosis (TB). Because KINERET is a medicine that affects your immune system and may lower your risk to fight infection, your doctor may test for TB and treat new or unknown TB, before you start taking KINERET.

You Should Know: Signs and symptoms of a serious infection could include fever, chills, or excessive sweating, open sores on your body, nausea, lightheadedness, or vomiting, dizziness or lightheadedness.

You should tell your healthcare provider or get medical help if new symptoms of an infection appear. They can be life-threatening or cause death.

You should stop using KINERET and call your healthcare provider or get emergency help right away if you have any of these symptoms of an allergic reaction: swelling of your face, lips, mouth, or tongue; trouble breathing; wheezing; severe itching; skin rash, redness, or swelling outside of the injection site area; dizziness or fainting; fast heartbeat or pounding in your chest (tachycardia); or sweating. People with DIRA may have an increased risk of allergic reactions, especially in the first several weeks.

It is not known if treatment with medicines that cause immunosuppression, like KINERET, affect your risk of getting cancer.

KINERET may cause you to have a lower number of certain white cells (neutrophils). Neutrophils are important in fighting infections. You should have blood tests before starting treatment with KINERET, then monthly for 3 months. After the first 3 months you should have your blood tested every 3 months for up to 1 year.

Before taking KINERET, you should tell your healthcare provider about all your medical conditions and medicines including prescription and over-the-counter medicines, vitamins, supplements, and herbal remedies.

What are other possible side effects of KINERET?

The most common side effects of KINERET include injection site skin reactions, worsening RA (if you already have RA), headache, nausea and vomiting, diarrhea, joint pain, fever, general feeling of discomfort, sore throat or runny nose, sinus infection, and pain in your stomach area.

You Should Know: These are not all the possible side effects for KINERET. For more information, ask your healthcare provider or review the Prescribing Information for KINERET at https://www.kineretrx.com/pdf/Full-Prescribing-Information-English.pdf.

If you suspect that you have experienced a side effect, call your healthcare provider. You may also report them to the US Food and Drug Administration (FDA) at 1-800-FDA-1088.

You Should Know: These are not all the possible side effects for KINERET. For more information, ask your healthcare provider or review the Prescribing Information for KINERET at https://www.kineretrx.com/pdf/Full-Prescribing-Information-English.pdf.

If you suspect that you have experienced a side effect, call your healthcare provider. You may also report them to the US Food and Drug Administration (FDA) at 1-800-FDA-1088.

This information is intended for US healthcare professionals. Please confirm you are a healthcare professional to continue.